Breo Ellipta vs Dulera – Comparison

Breo Ellipta

It is the brand name of a combination of fluticasone and vilanterol. Fluticasone belongs to a group of drugs known as corticosteroids that help reduce the irritation and swelling in the walls of the small air passages in the lungs and reduce inflammation in the lungs.

Vilanterol belongs to a group of drugs called bronchodilators that relax the muscles in the walls of the small air passages in the lungs.

Uses

It is used to treat asthma as well as a long-term treatment to control shortness of breath, wheezing, coughing, and chest tightness caused by the chronic obstructive pulmonary disease.

Dosage

The usual recommended dose of the medication is 1 inhalation a day.

Notes – use the medication at the same time each day, and not more than once in a 24-hour period. Also, do not use it to treat sudden symptoms of your health condition.

Patients with sensitivities to any component of the medication or individuals with allergies to milk or milk proteins should not use it.

Side Effects and Precautions

Common side effects may include:

  • a hoarse voice;
  • joint pain;
  • a sore throat;
  • back pain;
  • runny or stuffy nose;
  • headaches;
  • flu symptoms.

Rare side effects may include:

  • a cough with yellow or green mucus;
  • anxiety;
  • chills;
  • seeing halos around lights;
  • fast or pounding heartbeats;
  • eye pain;
  • fever;
  • pounding in your neck or ears;
  • tunnel vision;
  • chest pain;
  • blurred vision;
  • pain when swallowing;
  • white patches in the mouth and throat;
  • a feeling like you might pass out;
  • vomiting;
  • feeling very weak or tired.

To make sure that this medication is safe for you, tell your healthcare provider if you have:

  • liver disease;
  • a weak immune system;
  • glaucoma or cataracts;
  • high blood pressure;
  • a thyroid disorder;
  • heart disease;
  • type 2 diabetes mellitus;
  • a personal history of osteoporosis;
  • any type of infection, including  herpes infection of the eyes or tuberculosis;
  • seizures.
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Drug Interactions

It may negatively interact with other medications, especially:

  • antidepressants;
  • antifungal medication;
  • depakote;
  • diuretic or water pills;
  • antibiotics;
  • cetirizine;
  • medicines to treat HIV or AIDS;
  • MAO inhibitors, such as – linezolid, isocarboxazid, methylene blue injection, phenelzine, and tranylcypromine;
  • beta-blockers, such as – atenolol, metoprolol, carvedilol, labetalol, propranolol, nebivolol, and sotalol.

Pregnancy & Breastfeeding

It is not known precisely if this medication is excreted in human breast milk and negatively affects the infant. Therefore, contact your doctor before using the medication if you are breast-feeding a baby.

Moreover, since there are no well-done studies to determine its safety during pregnancy, it should only be used in pregnant women if the potential benefit justifies the potential risk to the fetus.

Duleradrugs

It is a medicine which contains a combination of mometasone furoate (a man-made anti-inflammatory corticosteroid) and formoterol (a long-acting beta-2 adrenergic agonist bronchodilator that relaxes muscles in the airways).

The medication is produced by Merck and Co., Inc., one of the largest pharmaceutical companies in the world. It was originally approved by the US Food and Drug Administration in 2010.

Uses

It is typically indicated for the treatment of chronic obstructive pulmonary disease and exercise-induced bronchospasm, and asthma in adults and children 12 years of age and older.

Dosage

The initial recommended dose is 2 inhalations of 100mcg/5mcg or 200mcg/5mcg two times per day (morning and evening).

The maximum recommended dose is 2 inhalations of 200mcg/5mcg two times per day.

Note – to prevent yeast infections of the mouth, rinse mouth after use.

Side Effects And Precautions

Common side effects may include:

  • a sore throat;
  • changes in menstrual periods;
  • back pain;
  • headaches;
  • skin rash, itching;
  • muscle cramps;
  • dizziness;
  • a stuffy nose;
  • dry mouth;
  • sleep problems (insomnia);
  • hoarseness or deepened voice;
  • anxiety;
  • sinus pain.
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Less common side effects may include:

  • increased thirst or hunger;
  • muscle weakness or limp feeling;
  • eye pain;
  • white patches in the mouth or throat;
  • seizure;
  • worsening asthma symptoms;
  • blurred vision;
  • urinating more than usual;
  • leg discomfort;
  • seeing halos around lights;
  • uneven heart rate;
  • fast or pounding heartbeats;
  • breathing problems;
  • restless feeling;
  • chest pain;
  • increased urination;
  • changes in the shape or location of body fat;
  • tremors;
  • wheezing.

Drug Interactions

It may negatively interact with other medications, especially:

  • anti-HIV medications, like – lopinavir-ritonavir (Kaletra) and ritonavir (Norvir);
  • antifungal medicines, like – ketoconazole (Nizoral).

Pregnancy & Breastfeeding

There are no well-done studies to determine whether this drug will negatively affect an unborn baby. Hence, tell your doctor if you are pregnant or plan to fall pregnant. Also, it may pass into the breast-milk and affect the infant in a negative way.

To make sure you can safely use this medication, tell your doctor if you have any of the following conditions:

  • type 2 diabetes mellitus;
  • heart disease;
  • low bone mineral density;
  • tuberculosis;
  • kidney disease;
  • a thyroid disorder;
  • liver disease;
  • an active infection of any kind;
  • glaucoma or cataracts;
  • herpes infection of the eye;
  • epilepsy or other seizure disorder.

Bottom Line – Breo Ellipta vs Dulera

Breo Ellipta inhalation powder (active ingredients – fluticasone and vilanterol) works by relaxing muscles in the airways as well as it prevents the release of substances in the body which cause inflammation.

Note – it is important to remember that this medication is intended for long-term relief and is not intended for immediate relief.

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Dulera (active ingredients – mometasone and formoterol) is an inhaled medication that is used to control and prevent asthma symptoms, such as – wheezing, in adults and children 12 years and older.

References

https://www.accessdata.fda.gov/drugsatfda_docs/label/2015/204275s002lbl.pdf
https://www.sciencedirect.com/science/article/pii/S0954611115301025

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