Odefsey vs Genvoya - Comparison of Side Effects & Uses

Odefsey

It is the brand name of a combination of rilpivirine, emtricitabine, and tenofovir. This medication belongs to a group of drugs called antivirals. It works by decreasing the amount of human immunodeficiency virus in the blood.

Uses

This prescription medication is used to treat HIV in adults and children who are at least 12 years old.

Human immunodeficiency virus is a virus that attacks the immune system. AIDS (acquired immunodeficiency syndrome) is a condition caused by HIV. Symptoms of early human immunodeficiency virus infection may include:

  • chills;
  • tiredness;
  • weakness;
  • joint pain;
  • unintentional weight loss;
  • enlarged glands;
  • a red rash;
  • fever;
  • sweats;
  • muscle aches.

Note – this medicine is not a cure for HIV or AIDS.

Dosage

For adults and children 12 years of age and older with body weight greater than 35 kg, the usual recommended dose is one tablet taken orally once a day with a meal.

Side Effects and Precautions

Common side effects may include:

  • changes in the shape or location of body fat;
  • tiredness;
  • diarrhea;
  • dizziness;
  • nausea;
  • strange dreams;
  • headaches;
  • rash;
  • sleep problems (insomnia);
  • depressed mood.

Rare side effects may include:

  • weight loss;
  • suicidal thoughts or actions;
  • wheezing;
  • unusual thoughts or behavior;
  • a dry cough;
  • constipation;
  • chest pain;
  • severe depression;
  • confusion;
  • sores on your genital or anal area;
  • loss of appetite;
  • loss of interest in sex;
  • increased thirst;
  • swollen glands;
  • trouble breathing;
  • problems with balance;
  • swelling of your feet or ankles;
  • impotence;
  • painful urination;
  • jaundice (yellowing of the skin or eyes);
  • night sweats;
  • upper stomach pain;
  • fever;
  • muscle weakness;
  • feeling anxious or irritable;
  • severe numbness;
  • severe lower back pain;
  • clay-colored stools;
  • trouble speaking;
  • menstrual changes.

Contraindications

To make sure that his medication is safe for you, tell your healthcare provider if you have ever had:

  • long QT syndrome;
  • kidney disease;
  • depression or mental illness;
  • liver disease.

Alcoholalcohol

Do not drink alcoholic beverages while taking this medication since alcohol use may increase the risk of severe side effects.

Drug Interactionsdrugs

It may negatively interact with other medications, especially:

  • clonazepam;
  • Adderall (amphetamine/dextroamphetamine);
  • gabapentin;
  • aspirin;
  • lisinopril;
  • atorvastatin;
  • omeprazole;
  • baclofen;
  • ranitidine;
  • bupropion;
  • testosterone;
  • citalopram;
  • Tivicay (dolutegravir);
  • lorazepam;
  • Xanax (alprazolam);
  • prednisone;
  • trazodone;
  • rosuvastatin.

Pregnancy & Breastfeeding

Women with HIV or AIDS should not breast-feed an infant. Even if your baby is born without human immunodeficiency virus, the virus may be passed to the baby through your breast milk.

If you are pregnant, your name may be listed on a pregnancy registry to evaluate any effects of this medication on the developing fetus.

Genvoya

It is the brand name of a combination of emtricitabine, cobicistat, tenofovir, and elvitegravir.

Cobicistat is a drug which works by reducing the action of enzymes in the liver that break down certain antiviral medications.

Emtricitabine, elvitegravir, and tenofovir are antiviral drugs that prevent human immunodeficiency virus from multiplying in the human body.

Together, these medications are antiretroviral drugs.

Uses

This prescription medication is typically used to treat human immunodeficiency virus.

Important note – this medication can’t cure HIV/AIDS, but it helps the people with HIV taking it regularly live longer.

Dosage

For patients 12 years and older who weigh ≥35kg, the usual recommended dosage is 1 tablet taken orally once per day.

Side Effects

Common side effects may include:

  • fatigue;
  • diarrhea;
  • nausea;
  • headaches.

Rare side effects may include:

  • vomiting;
  • indigestion;
  • pain in the right side of the stomach;
  • rash;
  • loss of appetite;
  • flatulence;
  • dark-colored urine;
  • abdominal pain;
  • light-colored bowel movements;
  • yellowing of the skin or the whites of the eyes.

Precautions

Before taking this medication, tell your healthcare professional:

  • if you have kidney problems;
  • if you are using hormone-based birth control, like – implants, pills, or vaginal rings;
  • if you have any other medical conditions;
  • if you are breastfeeding or plan to breastfeed;
  • if you are pregnant or plan to become pregnant;
  • about other OTC and prescription medicines, nutritional supplements, vitamins, and herbal products you plan to take or are taking;
  • if you have liver problems, such as – hepatitis B virus infection;
  • if you are allergic to any other medicines.

Drug Interactions

It may negatively interact with other medications, especially:

  • simvastatin;
  • lurasidone;
  • oral midazolam;
  • pimozide;
  • lovastatin;
  • dihydroergotamine;
  • triazolam;
  • methylergonovine;
  • sildenafil;
  • geodon;
  • phenytoin;
  • alfuzosin;
  • carbamazepine;
  • phenobarbital;
  • rifampin.

Pregnancy & Breastfeeding

If you are pregnant, your name may be listed on a pregnancy registry to evaluate any effects of this medication on the developing fetus.

Women with HIV or AIDS should not breast-feed an infant. Even if your baby is born without human immunodeficiency virus, the virus may be passed to the baby through your breast milk.

Alcohol

Do not drink alcoholic beverages while taking this medication since alcohol use may increase the risk of severe side effects.

Bottom Line – Odefsey vs Genvoya

Odefsey (active ingredients – emtricitabine, rilpivirine, and tenofovir) is a medication which is used to treat HIV, the virus that can cause acquired immunodeficiency syndrome. This medication should not be taken together with other antiviral medications to treat HIV or AIDS.

Genvoya (active ingredients – elvitegravir, emtricitabine, cobicistat, and tenofovir) is a medication that is used to treat human immunodeficiency virus in adults. It works by blocking a chemical in the body that is required for HIV-1 to multiply as well as it increases the number of T cells.

In conclusion, both medications can either be used in people who are starting HIV treatment and have never taken HIV-1 medicines before or in sufferers who are replacing their current HIV medications and whose doctor determines they meet certain requirements.

Also, Odefsey is a good choice if:

  • you don’t intend to miss doses;
  • you will be able to take your medicines daily with a full meal;
  • you don’t take medications for ulcers or heartburn;
  • your CD4 count is above 200;
  • your viral load is below 100,000.

Genvoya is a good choice if don’t take medications which interact, including certain steroid sprays for allergies or asthma.

References

https://www.odefsey.com/hcp/clinical-efficacy-trials/treatment-naive-adults
http://www.ema.europa.eu/ema/index.jsp?curl=pages/medicines/human/
https://www.sciencedirect.com/science/article/pii/S2211383518300789