Durezol vs Prednisolone Acetate - Comparison of Side Effects & Uses

Durezol

It is the brand name of a drug called difluprednate ophthalmic that belongs to the class of drugs called corticosteroids.

This medication works by reducing the inflammation and pain caused by cataract surgery.

Uses

It is typically used for the treatment of inflammation and pain associated with ocular surgery as well as for the treatment of endogenous anterior uveitis (inflammation which affects the front part of the eye).

Dosage

For uveitis, the usual recommended adult dose is 1 drop into the conjunctival sac of the affected eye 4 times a day for 2 weeks.

For postoperative ocular inflammation, the usual recommended dose is 1 drop into the conjunctival sac of the affected eye 4 times per day for 2 weeks starting 24 hours after surgery.

Notes – since a contaminated dropper can infect your eye and could lead to serious vision problems, do not touch the tip of the eye dropper or place it directly on your eye.

Also, wait fifteen minutes before using any other eye drops your healthcare provider has prescribed.

Side Effects and Precautions

Common side effects may include:

  • blurred vision;
  • headaches;
  • dry or watery eyes;
  • mild burning or itching of the eyes;
  • increased sensitivity of the eyes to light;
  • feeling like something is in the eye.

Rare side effects may include:

  • seeing halos around lights;
  • sudden eye redness;
  • a severe headache;
  • slow healing after your eye surgery;
  • tunnel vision;
  • sudden vision changes;
  • eye pain;
  • pain behind your eyes;
  • changes in the appearance or color of your iris (the colored part of your eye);
  • crusting of your eyes;
  • signs of a new eye infection.

Contraindications

This corticosteroid should not be used if you have the following conditions:

  • viral diseases of the cornea and conjunctiva;
  • mycobacterial infection of the eye;
  • fungal diseases of ocular structures;
  • epithelial herpes simplex keratitis, vaccinia, and varicella.

Pregnancy & Breastfeeding

It is not exactly known whether this corticosteroid passes into breast milk or if it could negatively affect the baby. Tell your healthcare provider if you are breastfeeding an infant.

Additionally, it is not known precisely whether this corticosteroid will harm an unborn baby. Tell your healthcare professional if you are pregnant or plan to fall pregnant.

Prednisolone Acetate

It is the generic name for a brand medication called Pred Forte. It belongs to a class of drugs called steroids.

This medication works by preventing redness and swelling by changing the way the immune system works.

Uses

It is used to reduce the redness, irritation, swelling, and burning of eye inflammation caused by heat, chemicals, infection, radiation, or allergy of the eye. It is occasionally used after eye surgery.

Dosage

The usual recommended dose is 1 to 2 drops into the conjunctival sac 2 to 4 times per day.

Notes – your vision may be blurry for a short amount of time after using the eye ointment. Avoid touching the tip of the tube against your eye.

Side Effects and Precautions

Common side effects may include:

  • increased sensitivity to light;
  • allergic reactions;
  • burning of the eyes, especially after applying this medication;
  • feeling like something is in the eye;
  • visual disturbance (blurry vision);
  • temporary cloudy vision.

Rare side effects may include:

  • severe headache;
  • pain behind your eyes;
  • tunnel vision;
  • sudden vision changes;
  • blurred vision;
  • seeing halos around lights;
  • sudden eye irritation;
  • eye pain;
  • signs of a new eye infection;
  • seeing halos around lights.

Pregnancy & Breastfeeding

It is not known exactly whether this medication passes into breast milk or if it could negatively affect the infant. Therefore, do not use it without telling your healthcare provider if you are breastfeeding an infant.

It is classified as a pregnancy category C medication by the US FDA, meaning that it is not known whether this medication is harmful to an unborn baby.

Bottom Line – Durezol vs Prednisolone Acetate

Durezol (active ingredient – difluprednate ophthalmic emulsion) is a steroid medicine that is used to treat anterior uveitis as well as eye inflammation and pain caused by eye surgery. It works by preventing the release of substances in the human body which cause inflammation.

Prednisolone acetate (brand name – Pred Forte) is used to treat redness, swelling, itching, and allergic reactions in the eye. It works by preventing the release of substances in the human body which cause inflammation.

According to studies, difluprednate is at least as effective as prednisolone in resolving the pain and inflammation associated with endogenous anterior uveitis.

References

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2938279/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4581692/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3130919/

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