Dyazide vs Lisinopril

Dyazide vs Lisinopril – detailed comparison:


It is the brand name of a combination of hydrochlorothiazide and triamterene. The medication belongs to a group of drugs called diuretics, and it causes the kidneys to get rid of water and sodium while holding on to potassium.

Triamterene is a potassium-sparing diuretic that also keeps potassium levels from getting too low and prevents the body from absorbing too much sodium. Hydrochlorothiazide is a thiazide diuretic that helps prevent the body from absorbing too much sodium.


This prescription medication is used to treat edema and high blood pressure.


For edema and hypertension sufferers, the treatment varies between 25 to 75 mg per day, taken once in the morning with food.

Side Effects and Precautions

Common side effects may include:

  • headaches;
  • constipation;
  • dizziness;
  • diarrhea;
  • dry mouth;
  • nausea;
  • blurred vision;
  • stomach pain.

Rare side effects may include:

  • fast, slow, or uneven heart rate;
  • blurred vision;
  • severe pain in the upper stomach spreading to your back;
  • vomiting;
  • seeing halos around lights;
  • jaundice (yellowing of the skin or eyes);
  • eye pain;
  • clay-colored stools;
  • tunnel vision;
  • a sore throat;
  • a light-headed feeling like you might pass out;
  • fever;
  • dark urine;
  • leg cramps;
  • muscle weakness or limp feeling;
  • increased thirst or urination;
  • loss of movement in any part of the body;
  • fluttering in your chest;
  • unusual thoughts or behavior;
  • muscle pain;
  • feeling tired or short of breath;
  • stomach pain;
  • swollen glands;
  • feeling restless or light-headed;
  • painful or difficult urination;
  • chest pain;
  • swelling of the feet or ankles;
  • little or no urination.

To make sure that this diuretic is safe for you, tell your healthcare provider if you have:

  • cirrhosis or another liver disease;
  • type 2 diabetes Mellitus;
  • gout;
  • a history of cataracts or glaucoma;
  • heart rhythm disorder;
  • if you are on a low-sodium diet;
  • heart disease;
  • an allergy to sulfa drugs or penicillin;
  • a history of kidney stones.

Drug Interactions

Tell your healthcare professional about all your current medicines and any other medicine you’ve started or stopped using, especially:

  • digoxin;
  • all your blood pressure medications;
  • methenamine;
  • valsartan;
  • amphotericin B;
  • oral diabetes medication;
  • chlorpropamide;
  • steroid medication (prednisone and others);
  • laxatives;
  • nonsteroidal anti-inflammatory drugs, such as – ibuprofen (Advil, Motrin), aspirin, diclofenac, naproxen (Aleve), indomethacin, or meloxicam;
  • lithium;
  • an ACE inhibitor, such as – captopril, benazepril, lisinopril, fosinopril, perindopril, moexipril, ramipril, or trandolapril;
  • a blood thinner.

Pregnancy & Breastfeeding

This diuretic can pass into breast milk and may negatively affect a nursing baby. Therefore, you should not breastfeed while using it.

Also, it is not known exactly whether it will harm an unborn baby. Tell your healthcare provider if you are pregnant or plan to become pregnant.


This drug belongs to a group of drugs called angiotensin-converting enzyme inhibitors. It works by relaxing blood vessels to make the heart pump better and lower blood pressure.

The medication can be found under the following brand names: Prinivil, Qbrelis, and Zestril.

The US FDA first approved this medication in 1987.


It is used to treat diabetic hypertension, congestive heart failure, and nephropathy.

Hypertension is a condition that can cause severe damage to the kidneys, heart, brain,  blood vessels, and other parts of the human body. Damage to these organs may lead to heart attack, heart disease, kidney failure, a heart failure, stroke, loss of vision, and other health problems.

Also, this angiotensin-converting enzyme inhibitor is used immediately after a heart attack in order to reduce the chance of having another heart attack.


Most doctors will recommend that the sufferer starts with a low dose, such as – 5mg, as the body gets used to taking the medication. A few weeks later, the dose can be increased until the sufferer reaches the optimal dose.

Important note – the peak effect of this angiotensin-converting enzyme inhibitor can be observed in 6 to 8 hours. Its effect lasts for an average duration of 24 hours.

Also, it is not recommended for children less than 6 years of age.

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Side Effects and Precautions

Common side effects may include:

  • headaches;
  • chest pain;
  • dizziness;
  • a cough.

Rare side effects may include:

  • irregular heartbeats;
  • a sore throat;
  • tired feeling;
  • a feeling like you might pass out;
  • loss of appetite;
  • weakness;
  • swelling of your feet or ankles;
  • fever;
  • dark urine;
  • loss of movement;
  • feeling short of breath;
  • upper stomach pain;
  • clay-colored stools;
  • nausea;
  • jaundice (yellowing of the skin or eyes).

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Drug Interactions

This angiotensin-converting enzyme inhibitor may negatively interact with other medications, especially:

  • celecoxib (Celebrex);
  • amiloride (Midamor);
  • angiotensin receptor blockers, such as – candesartan (Atacand) and telmisartan (Micardis);
  • hydrochlorothiazide;
  • nabumetone (Relafen);
  • spironolactone (Aldactone);
  • naproxen sodium (Aleve);
  • aliskiren (Tekturna);
  • indomethacin (Indocin);
  • triamterene (Dyrenium);
  • ketoprofen (Orudis, Oruvail);
  • furosemide (Lasix);
  • potassium supplements;
  • ibuprofen (Advil, Motrin);
  • torsemide (Demadex);
  • lithium (Eskalith, Lithobid);
  • ketorolac (Toradol);
  • naproxen (Naprosyn);
  • piroxicam (Feldene);
  • diclofenac (Cambia, Zipsor);
  • meloxicam (Mobic);
  • etodolac (Lodine);
  • injectable gold (sodium aurothiomalate);
  • oxaprozin (Daypro).


Drinking alcohol can increase the blood pressure-lowering effect of this angiotensin-converting enzyme inhibitor and can also make you feel dizzier and more likely to faint.

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Pregnancy & Breastfeeding

Avoid this angiotensin-converting enzyme inhibitor as soon as possible once the pregnancy is detected. Also, it should be avoided by nursing women.

Bottom Line – Dyazide vs Lisinopril

Dyazide (active ingredients – hydrochlorothiazide and triamterene) is a medication that is given to individuals in whom other diuretics have caused hypokalemia. The medication is used to treat fluid retention and high blood pressure.

Lisinopril (brand names: Prinivil, Qbrelis, Zestril) is a medication that is prescribed to patients with high blood pressure. Additionally, the medication is given to people with kidney problems without hypertension as a preventive measure.

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