Dexilant vs Omeprazole – Comparison of Uses & Side Effects

Dexilant

It is the brand name of a medication called dexlansoprazole, which is part of a group of medications known as proton pump inhibitors.

Uses

This prescription medication is used to treat heartburn related to acid-related damage to the lining of the esophagus (erosive esophagitis, or EE) and gastroesophageal reflux disease.

Mechanism of Action

It works by reducing the amount of acid the stomach produces.

Contraindications

Before taking this proton pump inhibitor, tell your healthcare provider if you have:

  • osteoporosis;
  • low levels of magnesium in your blood;
  • low bone mineral density (osteopenia);
  • severe liver disease.

Dosage

For erosive esophagitis, the usual recommended dosage is one 60 mg capsule once a day for up to 8 weeks.

Pregnancy & Breastfeeding

It is not known whether this proton pump inhibitor passes into human breast milk or if it could negatively affect a breastfed infant.

There are no studies to determine whether this proton pump inhibitor is safe to use during pregnancy. Tell your doctor if you are pregnant before using this medication.

Side Effects and Precautions

Common side effects may include:

  • diarrhea;
  • sore throat;
  • nausea;
  • gas;
  • headache;
  • sinus pain;
  • mouth pain;
  • stomach pain;
  • vomiting;
  • stuffy nose.

Less common side effects may include:

  • trouble moving your hip, wrist, or back;
  • rapid weight gain;
  • fast or uneven heart rate;
  • diarrhea that is watery or bloody;
  • feeling short of breath;
  • mood changes;
  • tiredness;
  • severe stomach pain;
  • blood in your urine;
  • dizziness;
  • feeling jittery;
  • muscle spasms in your hands and feet;
  • a seizure (convulsions).

Drug Interactions

It may negatively interact with other medications, especially:

  • Strattera;
  • rifampin;
  • voriconazole;
  • digoxin;
  • HIV or AIDS medicines, such as – nelfinavir, ritonavir, saquinavir;
  • St. John’s wort;
  • methotrexate;
  • warfarin (Coumadin);
  • diuretics.
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Alcoholalcohol

Avoid drinking alcoholic beverages while taking this proton pump inhibitor since alcohol use can notably increase the risk of side effects.

Omeprazoleg

It is the generic name of a medication, that is part of a family of medications known as proton pump inhibitors. This medication is found under the brand name of Prilosec. It was first approved by the US FDA in 1989.

Uses

This medication is used to treat erosive esophagitis, Zollinger-Ellison syndrome (a condition in which one or more tumors form in the upper part of the small intestine or the pancreas), certain types of ulcers, gastroesophageal reflux disease, and infections caused by the bacteria H. pylori.

Mechanism of Action

It works by reducing the amount of acid made in the stomach.

Contraindications

Before taking this proton pump inhibitor, tell your doctor if you have:

  • low bone mineral density;
  • bloody or black stools;
  • low levels of magnesium in the blood;
  • heartburn with wheezing;
  • heartburn which has lasted for over 3 months;
  • nausea or vomiting;
  • frequent chest pain;
  • pain with swallowing;
  • vomit that looks like coffee grounds;
  • stomach pain;
  • liver disease;
  • unexplained weight loss.

Dosage

The usual recommended dosage is 20 mg orally once a day before a meal.

Drug Interactions

It may negatively interact with other medications, especially:

  • hydrocodone;
  • diazepam;
  • levothyroxine;
  • ibuprofen;
  • Xanax (alprazolam);
  • Neurontin (gabapentin);
  • Zoloft (sertraline);
  • albuterol;
  • Tylenol (acetaminophen);
  • gabapentin;
  • Singulair (montelukast);
  • dextroamphetamine;
  • rozerem;
  • Lipitor (atorvastatin);
  • Plavix (clopidogrel);
  • aspirin;
  • Cymbalta (duloxetine);
  • Lasix (furosemide);
  • Cipro (ciprofloxacin);
  • lisinopril.

Side Effects and Precautions

Common side effects may include:

  • diarrhea;
  • nausea;
  • stomach pain;
  • headaches;
  • excessive gas;
  • vomiting.
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Less common side effects may include:

  • severe stomach pain;
  • fast heartbeats;
  • feeling irritable;
  • a rash or joint pain;
  • muscle cramps;
  • blood in your urine;
  • rapid weight gain;
  • diarrhea that is watery or bloody;
  • unusual pain in your hip, wrist, thigh, or back;
  • urinating more or less than usual;
  • confusion;
  • seizure (convulsions).

Alcohol

Avoid drinking alcoholic beverages while taking this drug since alcohol use can increase the risk of side effects.

Pregnancy & Breastfeeding

There are no studies to determine whether this proton pump inhibitor is safe to use during pregnancy.

This proton pump inhibitor passes into breast milk and the effects on a nursing infant are not known. You should talk to your doctor before breastfeeding a baby while taking this medication.

Bottom Line – Dexilant vs Omeprazole

Dexilant (active ingredient – dexlansoprazole) is a proton pump inhibitor that is used to treat gastroesophageal reflux disease. This drug relies on a dual delayed-release action to reduce the acid in your stomach. It is part of a group of medications known as proton pump inhibitors.

Omeprazole (brand name – Prilosec) is a drug which belongs to a class of drugs called proton pump inhibitors. It is used to treat symptoms of gastroesophageal reflux disease, Zollinger-Ellison syndrome, certain types of ulcers, and infections caused by the bacteria H. pylori.

According to a 2015 study, compared to other PPIs, Dexilant has a unique mechanism of releasing the active ingredient. Consequently, the medication concentration in the blood and the proton pump inhibition effect are maintained for much longer.

Regarding their price, the average retail price for 30 capsules of Dexilant 60mg is $290, while the average retail price for 60 capsules of omeprazole 20mg is $18.

References

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4839877/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4930293/
https://clinicaltrials.gov/ct2/show/NCT00251719

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