Adzenys vs Adderall

Adzenys vs Adderall – detailed comparison:

Adzenys XR-ODT

It is the brand name of a drug called amphetamine, which belongs to a group of drugs known as amphetamine stimulants.

Mechanism of Action

This drug works by improving focus and decreasing hyperactivity by altering the levels of certain natural chemicals in the brain.

It was originally approved by the US FDA on January 27, 2016.


This prescription medication is used to treat attention deficit hyperactivity disorder in adults and children aged 6 years and older.

ADHD is a condition that involves excessive activity, difficulty paying attention, sitting still, and controlling behavior.

If left untreated, ADHD may negatively affect the sufferer, as well as his family life, since over 65% of children with this condition may still exhibit symptoms into adulthood.


The usual recommended dose is 1.5 mg per day. It is commonly taken in the morning.

Side Effects and Precautions

Common side effects may include:

  • unpleasant taste in the mouth;
  • constipation;
  • sleep problems (insomnia);
  • diarrhea;
  • dry mouth;
  • vomiting;
  • increased heart rate;
  • nausea;
  • itching;
  • stomach pain;
  • sexual problems;
  • weight loss;
  • dizziness;
  • loss of appetite;
  • headaches;
  • nosebleeds;
  • a runny nose;
  • feeling restless or nervous;
  • mood changes.

Rare side effects may include:

  • a seizure (convulsions);
  • feeling like you might pass out;
  • paranoia;
  • trouble breathing;
  • skin color changes in your fingers or toes;
  • chest pain;
  • hostility;
  • changes in your vision;
  • aggression;
  • muscle twitches (tics);
  • unexplained wounds;
  • cold feeling;
  • hallucinations (seeing or hearing things that are not real).


Before taking this stimulant, tell your healthcare provider if you have:

  • a history of drug or alcohol addiction;
  • severe anxiety, tension, or agitation;
  • overactive thyroid;
  • moderate to severe high blood pressure.


Avoid drinking alcoholic beverages while taking this stimulant since alcohol use can substantially increase the risk of severe side effects.

Drug Interactions

It may negatively interact with other medications, especially:

  • cyclobenzaprine;
  • alprazolam;
  • methylphenidate;
  • amphetamine/dextroamphetamine;
  • phentermine;
  • bupropion;
  • Prozac (fluoxetine);
  • buspirone;
  • tracleer;
  • Vyvanse;
  • clonazepam;
  • Trintellix (vortioxetine);
  • duloxetine;
  • trazodone;
  • gabapentin;
  • sertraline;
  • lamotrigine;
  • montelukast;
  • levothyroxine.

Pregnancy & Breastfeeding

Do not use this medication if you are pregnant since taking the stimulant during pregnancy can cause low birth weight, premature birth, or withdrawal symptoms in the newborn baby.

It can pass into breast milk and may negatively affect a nursing infant. Tell your healthcare provider if you are breastfeeding an infant before using this stimulant.

Adderall XR

It is a central nervous system stimulant that contains 2 different chemicals – amphetamine and dextroamphetamine.

Mechanism of Action

It works as a central nervous system stimulant for increased concentration, attention span, and focus.


This central nervous system stimulant is used to treat ADHD.

In addition, it may prevent symptoms of narcolepsy that include sudden attacks of daytime sleepiness.

Side Effects And Precautions

Common side effects may include:

  • unexplained weight loss;
  • restlessness;
  • loss of appetite;
  • stomach pain;
  • uncontrollable shaking of a part of the body;
  • dry mouth;
  • changes in sex drive;
  • headaches;
  • diarrhea;
  • difficulty falling asleep;
  • constipation;
  • problems staying asleep;
  • erectile dysfunction;
  • nervousness;
  • vomiting;
  • nausea.

Less common side effects may include:

  • seizures;
  • fever (high temperature);
  • difficult speech;
  • pounding heartbeat;
  • shortness of breath;
  • feeling unusually suspicious of others;
  • abnormally excited mood;
  • chest pain;
  • hostile behavior;
  • numbness of an arm or leg;
  • difficulty breathing;
  • excessive tiredness;
  • blurred vision;
  • swelling of the eyes, face, tongue, or throat;
  • seeing things that do not exist;
  • hives;
  • hoarseness;
  • problems swallowing;
  • itching;
  • believing things that are not true;
  • rash;
  • faintness;
  • verbal tics;
  • peeling skin.

Drug Interactions

It may negatively interact with other medications, especially any of the following:

  • Prozac (fluoxetine);
  • ibuprofen;
  • Cymbalta (duloxetine);
  • Abilify (aripiprazole);
  • gabapentin;
  • Lexapro (escitalopram);
  • Vyvanse (lisdexamfetamine);
  • Advil (ibuprofen);
  • victoza;
  • Lamictal (lamotrigine);
  • Percocet (acetaminophen/oxycodone);
  • Norco (acetaminophen/hydrocodone);
  • Ambien (zolpidem);
  • Xanax (alprazolam);
  • clonazepam;
  • trazodone;
  • opsumit;
  • loryna;
  • Seroquel (quetiapine);
  • Ritalin (methylphenidate);
  • tramadol;
  • Suboxone (buprenorphine/naloxone);
  • prednisone;
  • Topamax (topiramate);
  • omeprazole;
  • gadovist;
  • Klonopin (clonazepam);
  • Zoloft (sertraline);
  • Wellbutrin (bupropion).

Pregnancy & Breastfeeding

There are no well-controlled clinical studies on pregnant women. Tell your healthcare provider that you are pregnant before using this medication.

In addition, there are no well-controlled studies to determine the safe use of this central nervous system stimulant by nursing women. Therefore, it may only be used if the potential benefits to the mother outweigh the potential risks to the breastfed baby.


This central nervous system stimulant is a US Food and Drug Administration approved drug. However, due to the fact that it has a high potential for abuse, it is in the category of controlled substances.

Signs and symptoms of overdose may include:

  • vertigo (a condition where an individual feels as if he or the objects around him are moving);
  • hallucinations;
  • panic attacks;
  • cardiac rhythm abnormalities;
  • profound confusion;
  • coma;
  • uncontrollable tremor;
  • loss of consciousness;
  • hyperventilation.


Avoid drinking alcoholic beverages while taking this medication since alcohol combined with stimulants substantially increases the risk of side effects.

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Bottom Line – Adzenys vs Adderall

Adzenys XR-ODT (active ingredient – amphetamine) is a medication that is used to treat attention deficit hyperactivity disorder. This medication works by affecting chemicals in the brain and nerves, which contribute to hyperactivity and impulse control.

Adderall XR (active ingredients – amphetamine and dextroamphetamine) is a medication that is prescribed for the treatment of ADHD. People diagnosed with ADHD are using this medication to help them concentrate and focus more.

Adzenys is an extended-release amphetamine, and it is the first extended-release drug for ADHD which dissolves in the mouth. Adderall XR is also an extended-release drug that was developed by Shire Pharmaceuticals.

They are both habit-forming and are classified as Schedule II controlled substances. Both medications last up to 12 hours.

Regarding their price, the average retail price for 30 orally disintegrating tabs of Adzenys XR-ODT 6.3mg is $335, while the average retail price for 30 capsules of Adderall XR 20mg is $75.

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