Abaloparatide vs Teriparatide - Comparison Between New Osteoporosis Drugs

Abaloparatide

It is the generic name of a drug which is a man-made version of the body’s natural parathyroid hormone. It can be found under the brand name of Tymlos.

Mechanism of Action

It works in bones to help build new bone and make bones stronger.

Uses

This prescription medication is used to treat osteoporosis in postmenopausal women.

Dosage

The usual recommended dose is 80 mcg subcutaneously once a day.

If your symptoms or health problems become worse or if they do not get better, call your healthcare provider.

Cumulative use of this medication and parathyroid hormone analogs for more than 2 years during a sufferer’s lifetime is not recommended.

Side Effects

Common side effects may include:

  • vomiting;
  • excessive thirst;
  • nausea;
  • unusual tiredness or weakness;
  • blood in urine;
  • pain in the stomach;
  • constipation;
  • muscle weakness;
  • depression;
  • loss of weight;
  • unexplained loss of appetite.

Rare side effects may include:

  • a sensation of spinning;
  • racing heartbeat or pulse;
  • a feeling of constant movement of self.

Precautions

Before taking this medication, tell your healthcare provider if you have:

  • kidney stones;
  • a bone disease other than osteoporosis;
  • a condition called hyperparathyroidism;
  • radiation treatment involving your bones;
  • alkaline phosphatase in your blood;
  • bone cancer;
  • high levels of calcium.

Alcohol

Avoid drinking alcoholic beverages while taking this medication since alcohol use can substantially increase the risk of severe side effects.

Drug Interactions

It may negatively interact with other medications, especially:

  • Digitek (digoxin);
  • betamethasone/calcipotriene topical;
  • Digox (digoxin);
  • tums;
  • calcipotriene topical;
  • Cardoxin;
  • Enstilar (betamethasone/calcipotriene topical);
  • Lanoxin;
  • Calcitrene (calcipotriene topical);
  • calcitriol topical;
  • Taclonex (betamethasone/calcipotriene topical);
  • Dovobet;
  • Vectical (calcitriol topical);
  • Dovonex;
  • Taclonex Scalp (betamethasone/calcipotriene topical);
  • Sorilux (calcipotriene topical);
  • Lanoxicaps.

Pregnancy & Breastfeeding

It is not known whether this medication passes into breast milk or if it could harm a nursing baby. Do not breastfeed a baby while using this medicine.

Also, this medication is for use only in women who can no longer get pregnant.

Teriparatide

It is the generic name of a drug, a synthetic hormone which is similar to the one the body makes naturally – parathyroid hormone. It can be found under the brand name of Forteo.

Mechanism of Action

It works by causing the body to build new bone and increase bone strength by regulating phosphate and calcium.

Uses

This prescription medication is used to treat both men and postmenopausal women with osteoporosis who are at high risk for having broken bones.

Dosage

It is given as a shot into the fatty part of the skin on the top of the thigh or the belly area.

The usual recommended dose is 20 mcg subcutaneously once a day.

Side Effects

Common side effects may include:

  • pain anywhere in your body;
  • joint pain;
  • nausea.

Rare side effects may include:

  • a feeling like you might pass out;
  • tired feeling;
  • fluttering in your chest;
  • lack of energy;
  • pounding heartbeats;
  • muscle weakness;
  • constipation.

Precautions

Before taking this medication, tell your healthcare provider if you have:

  • kidney stones;
  • Paget’s disease;
  • radiation treatment involving your bones;
  • a history of bone cancer;
  • a bone disease other than osteoporosis;
  • a condition called hyperparathyroidism;
  • alkaline phosphatase in your blood;
  • high levels of calcium.

Alcohol

Avoid drinking alcoholic beverages while taking this medication since alcohol use can substantially increase the risk of severe side effects.

Drug Interactions

It may negatively interact with other medications, especially:

  • digoxin;
  • digitalis;
  • Lasix (furosemide).

Pregnancy & Breastfeeding

This medication may be harmful to a developing fetus. Tell your healthcare provider if you are pregnant or plan to fall pregnant during treatment.

It is not known whether this medication passes into breast milk. Do not use this medication without telling your healthcare professional if you are breastfeeding an infant.

Bottom Line – Abaloparatide vs Teriparatide

Abaloparatide (brand name – Tymlos) is a man-made form of parathyroid that is used to treat osteoporosis in postmenopausal women who have a high risk of bone fracture. This medication works by increasing bone density and bone strength to help prevent fractures.

Teriparatide (brand name – Forteo) is a man-made form of a hormone called parathyroid that increases bone density and increases bone strength to help prevent fractures. It is used to treat osteoporosis in women and men who have a high risk of bone fracture.

According to a 2017 study, abaloparatide has demonstrated noninferiority to teriparatide regarding the increase in bone mass measurement at the lumbar spine and the reduction of vertebral fracture risk, whereas it has demonstrated a greater increase in bone mass measurement at the femoral sites.

Regarding their price, the average retail price for 1 pen (1.56ml) of Tymlos 80mcg/dose is $1,760, while the average retail price for 1 pen (2.4ml) of Forteo 20mcg/dose is $3,360.

References

https://www.ncbi.nlm.nih.gov/pubmed/27533157
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5553106/
https://www.sciencedirect.com/science/article/pii/S8756328216303295

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