Toradol vs Ibuprofen 800 - Comparison of Uses & Side Effects

Toradol

It is the brand name of a medication called ketorolac, that belongs to a group of drugs known as nonsteroidal anti-inflammatory drugs. It was originally approved by the US Food and Drug Administration in 1989.

Mechanism of Action

It works by stopping the body’s production of a substance that causes pain, fever, and inflammation.

Uses

This prescription medication is used for the short-term treatment of moderately severe pain following surgery.

In addition, it is used to treat itchy eyes caused by allergies and redness which can occur after cataract surgery as well as for cancer pain, back pain, and pain caused by kidney stones.

Dosage

This medicine is given in an oral and injection form. For acute pain, the usual recommended dose is 30 mg IV or 60 mg IM.

Note – it should not be used for longer than 5 days, including both injection and tablets. This medication is not approved for use by anyone younger than 2 years old.

Side Effects and Precautions

Common side effects may include:

  • swelling;
  • diarrhea;
  • headaches;
  • indigestion;
  • drowsiness;
  • stomach pain;
  • dizziness;
  • nausea.

Rare side effects may include:

  • skin rash;
  • rapid weight gain;
  • shortness of breath;
  • trouble concentrating;
  • coughing up vomit that looks like coffee grounds;
  • rapid heart rate;
  • bloody or tarry stools;
  • feeling tired;
  • pale skin;
  • jaundice (yellowing of the skin or eyes);
  • swelling of your feet or ankles;
  • clay-colored stools;
  • painful or difficult urination;
  • loss of appetite;
  • little or no urinating;
  • upper stomach pain.

Contraindications

Before taking this medication, tell your healthcare provider if you have:

  • liver disease;
  • if you smoke tobacco;
  • kidney disease;
  • stomach ulcers;
  • a blood clot;
  • asthma;
  • diabetes;
  • Crohn’s disease;
  • high cholesterol;
  • fluid retention;
  • stroke;
  • high blood pressure;
  • ulcerative colitis;
  • heart disease;
  • heart attack.

AlcoholAlcohol

Avoid drinking alcoholic beverages while taking this medication since alcohol use can substantially increase the risk of severe side effects.

Drug InteractionsDrug

It may negatively interact with other medications, especially:

  • diuretics (water pills);
  • Probenecid (Benemid);
  • medications for anxiety or mental illness;
  • blood thinners like warfarin;
  • sedatives;
  • tranquilizers;
  • aspirin or other NSAID, like – naproxen (Aleve, Naprosyn);
  • sleeping pills;
  • oral steroids, like – dexamethasone (Decadron) or prednisone (Deltasone);
  • Methotrexate (Rheumatrex);
  • medications for seizures, like – phenytoin (Dilantin) or carbamazepine (Tegretol);
  • antidepressants;
  • angiotensin-converting enzyme inhibitors, like – trandolapril (Mavik), captopril (Capoten), fosinopril (Monopril), enalapril (Vasotec), quinapril (Accupril).

Pregnancy & Breastfeeding

This medication may increase the risk of uterine bleeding, Also, using it during the last 3 months of pregnancy may harm the unborn baby.

It can pass into breast milk and may negatively affect a nursing infant. Do not breastfeed a baby while taking this nonsteroidal anti-inflammatory drug.

Ibuprofen 800

It is the generic name of a few brand medicines, like – Motrin or Advil.

Mechanism of Action

This medication is a nonsteroidal anti-inflammatory drug which works by reducing the production of prostaglandins.

The US Food and Drug Administration first approved it under the Motrin brand in 1974. It is produced by McNeil Consumer Healthcare, an American medical products company that belongs to the Johnson & Johnson healthcare group.

Uses

This medication is used to lower a high temperature, relieve the symptoms of fever and arthritis, and some types of pain, including:

  • migraines;
  • muscular pain;
  • nerve pain (neuralgia);
  • toothaches;
  • headaches;
  • sprains and strains;
  • backaches;
  • menstrual pain.

Dosage

To reduce pain, the usual recommended dosage for an adult is 200 to 400 mg orally every 4 to 6 hours as required. The maximum dose for adults is 3200 mg a day, divided into 3 or 4 doses.

Alcohol

It is not recommended to drink alcoholic beverages while taking a non-steroidal anti-inflammatory drug. Doing so could trigger potentially serious side effects.

Side Effects And Precautions

Common side effects may include:

  • mild itching or rash;
  • constipation;
  • dizziness;
  • nervousness;
  • diarrhea;
  • vomiting;
  • excessive gas;
  • ringing in the ears;
  • upset stomach;
  • mild heartburn;
  • nausea;
  • bloating.

Less common side effects may include:

  • shortness of breath;
  • a sore throat;
  • yellowing of the skin or eyes;
  • rapid weight gain;
  • dark urine;
  • swelling of the ankles, face, tongue, or feet;
  • feeling light-headed;
  • changes in your vision;
  • burning in the eyes;
  • skin pain followed by a purple skin rash;
  • rapid heart rate;
  • bloody or tarry stools;
  • clay-colored stools;
  • painful urination;
  • trouble concentrating;
  • little or no urinating;
  • coughing up blood;
  • loss of appetite.

Drug Interactions

It may negatively interact with other medications, especially:

  • aspirin (both pill and suppository forms);
  • antidepressants, like – Paxil (paroxetine) and Lexapro (escitalopram);
  • other non-steroidal anti-inflammatory drugs, such as – Celebrex (celecoxib) or Relafen (nabumetone);
  • robitussin;
  • Stirbild (elvitegravir/cobicistat/emtricitabine/tenofovir);
  • blood thinners, such as – Pradaxa (dabigatran) or Coumadin (warfarin);
  • cancer drugs, like – Alimta (Pemetrexed);
  • beta blockers, such as – Zebeta (bisoprolol) or Coreg (carvedilol);
  • Eliquis (apixaban);
  • nabumetone;
  • water pills.

Pregnancy & Breastfeedingt

It is not known exactly whether this medication passes into human breast milk or if it could negatively affect a breastfed infant. Tell your healthcare provider that you are breastfeeding a baby before using this medication.

Since there are no well-controlled clinical studies in pregnant women, this nonsteroidal anti-inflammatory drug is best to be avoided especially in late pregnancy because of the risk of premature closure of the ductus arteriosus in the fetal heart.

Bottom Line – Toradol vs Ibuprofen 800

Toradol (active ingredient – ketorolac) is a medication that is typically given before or after medical procedures. It works by blocking your body’s production of natural substances that cause inflammation.

Ibuprofen (brand names – Advil, Motrin, and Ibuprin) is a medication that belongs to a group of drugs known as non-steroidal anti-inflammatory drugs. It works by inhibiting prostaglandins, chemicals that can cause inflammation in the body and is used to lower a high temperature, relieve the symptoms of fever and arthritis, and some types of pain.

According to a 1998 study done at the Department of Emergency Services, San Francisco General Hospital, USA, Toradol and ibuprofen provide comparable levels of analgesia in ED patients presenting with moderate to severe pain.

Also, a 1994 study established that intravenous Toradol given at the conclusion of surgery was more effective than oral ibuprofen given 30 to 45 minutes after strabismus surgery in controlling postoperative pain.

Regarding their price, the average retail price for 10 vials (1ml) of ketorolac 30mg/ml is $18, while the average retail price for 90 tablets of ibuprofen 800 mg is $12.

References

https://www.ncbi.nlm.nih.gov/pubmed/27993418
http://www.annemergmed.com/article/S0196-0644(16)31244-6/abstract
https://www.sciencedirect.com/topics/neuroscience/

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