Tivicay vs Isentress – Comparison of Uses & Side Effects

Tivicay

It is the brand name of a drug called dolutegravir, that belongs to a group of drugs known as HIV integrase inhibitors.

Mechanism of Action

It works by increasing the number of immune cells which help fight infections in the body and decreasing the amount of HIV in the blood.

Uses

This prescription medication is used to treat human immunodeficiency virus infection.

Note – it does not cure HIV.

Dosage

For the treatment-naïve or treatment-experienced INSTI-naïve, the usual recommended dose is 50 mg per day.

Side Effects and Precautions

Common side effects may include:

  • sleep problems (insomnia);
  • tiredness;
  • headaches.

Rare side effects may include:

  • weight loss;
  • the first sign of any skin rash;
  • swollen glands;
  • jaundice (yellowing of the skin or eyes);
  • chest pain (especially when you breathe);
  • upper stomach pain;
  • sores on your genital or anal area;
  • clay-colored stools;
  • problems with balance or eye movement;
  • dark urine;
  • feeling short of breath;
  • loss of appetite;
  • weakness or prickly feeling;
  • vomiting;
  • loss of interest in sex;
  • nausea;
  • menstrual changes;
  • a dry cough;
  • swelling in your neck or throat;
  • loss of bladder or bowel control;
  • feeling anxious or irritable;
  • severe lower back pain;
  • rapid heart rate.

Contraindications

Before taking this HIV integrase inhibitor, tell your healthcare provider if you have:

  • liver disease.

AlcoholAlcohol

Avoid drinking alcoholic beverages while taking this HIV integrase inhibitor since alcohol use can substantially increase the risk of severe side effects.

Drug InteractionsDrug

It may negatively interact with other medications, especially:

  • clonazepam;
  • acyclovir;
  • Epzicom (abacavir/lamivudine);
  • amlodipine;
  • lisinopril;
  • epipen;
  • aspirin;
  • Norvir (ritonavir);
  • atorvastatin;
  • Prezcobix (cobicistat/darunavir);
  • bupropion;
  • ranitidine;
  • Complera (emtricitabine/rilpivirine/tenofovir);
  • Truvada (emtricitabine/tenofovir);
  • Descovy (emtricitabine/tenofovir alafenamide);
  • valacyclovir;
  • Edurant (rilpivirine);
  • Triumeq (abacavir/dolutegravir/ lamivudine);
  • gabapentin;
  • tramadol;
  • hydroxyzine;
  • votrient;
  • Prezista (darunavir);
  • omeprazole.

Pregnancy & Breastfeeding

There are no well-done studies to determine whether this HIV integrase inhibitor is safe to use during pregnancy. Tell your healthcare provider that you are pregnant or plan to fall pregnant before using this medicine.

Also, women with HIV or AIDS should not breast-feed an infant.

Isentress

It is the brand name of a drug called raltegravir, that belongs to a group of drugs known as integrase inhibitors.

Mechanism of Action

It works by blocking the activity of a substance in the HIV, called HIV integrase, that is needed to make more viruses.

Uses

This prescription medication is used to treat human immunodeficiency virus infection in combination with other anti-HIV medicines.

Dosage

For the treatment of naïve patients or patients who are virologically suppressed, the usual recommended dose is 400 mg twice daily.

Side Effects and Precautions

Common side effects may include:

  • sleep problems (insomnia);
  • nausea;
  • tired feeling;
  • dizziness;
  • headaches.

Rare side effects may include:

  • sores on your genital or anal area;
  • weight loss;
  • problems with balance or eye movement;
  • stomach pain;
  • swelling in your neck or throat;
  • diarrhea;
  • loss of interest in sex;
  • night sweats;
  • loss of bladder or bowel control;
  • fever (high temperature);
  • impotence;
  • feeling short of breath;
  • menstrual changes;
  • weakness or prickly feeling;
  • feeling anxious or irritable;
  • chest pain (especially when you breathe);
  • severe lower back pain.

Contraindications

Before taking this integrase inhibitor, tell your healthcare provider if you have:

  • mental illness or depression;
  • liver disease;
  • kidney disease;
  • a muscle disorder.

Alcohol

Avoid drinking alcoholic beverages while taking this integrase inhibitor since alcohol use can substantially increase the risk of severe side effects.

Drug Interactions

It may negatively interact with other medications, especially:

  • Cymbalta (duloxetine);
  • acyclovir;
  • Intelence (etravirine);
  • atorvastatin;
  • lisinopril;
  • bupropion;
  • Norvir (ritonavir);
  • clonazepam;
  • omeprazole;
  • Crestor (rosuvastatin);
  • Prezista (darunavir);
  • Descovy (emtricitabine/tenofovir alafenamide);
  • Truvada (emtricitabine/tenofovir);
  • Epzicom (abacavir/lamivudine);
  • trazodone;
  • fenofibrate;
  • metformin;
  • gabapentin;
  • lorazepam;
  • Lipitor (atorvastatin).

Pregnancy & Breastfeedingpregnant

There are no well-done studies to determine whether this integrase inhibitor is safe to use during pregnancy. Tell your healthcare provider that you are pregnant or plan to fall pregnant before using this medicine.

Also, women with HIV or AIDS should not breastfeed a baby.

Bottom Line – Tivicay vs Isentress

Tivicay (active ingredient – dolutegravir) is a medication that is used with other antiviral medications to treat HIV. It works by preventing human immunodeficiency virus from multiplying in your body.

Isentress (active ingredient – raltegravir) is a medication that is used to treat HIV. It works by preventing human immunodeficiency virus from multiplying in your body.

According to a 2013 study, once-daily Tivicay, in combination with up to two other antiretroviral drugs, is well tolerated with a substantially better virological effect compared with twice-daily Isentress.

Regarding their price, the average retail price for 30 tablets of Tivicay 50mg is $1,700, while the average retail price for 60 tablets of Isentress 400mg is $1,530.

References

http://www.ema.europa.eu/ema/index.jsp?curl=pages/medicines/human/
https://jamanetwork.com/journals/jama/article-abstract/1889129?redirect=true
http://www.nejm.org/doi/full/10.1056/NEJMoa1215541