What are the Health Benefits of Proline Amino acid

What is Proline?

This is a non essential amino acid that is synthesized by the body from the the non essential amino acids ornithine or glutamine and is involved in the body’s production of glutamic acid. It is the 3rd most abundant amino acid in the body.

It was first isolated in 1900 by Richard Willstatter, who obtained the amino acid while studying N-Methyl-L-proline.

It is different from other amino acids in that it has another amino group and contains a pyrrole ring (C4H4NH), such as found in hemoglobin and the cytochromes. This structure causes this amino acid in a protein to impart a rigid protein structure.

Health benefits

  • It is one of the main components of collagen. These collagen fibres are found in the ligaments, tendons and connective tissues of the body.
  • It also promotes the formation of bone, skin and cartilage and it is extremely essential for the proper functioning of joints and tendons.
  • It helps maintain and strengthen heart muscles and is important in tissue repair after injury, or for any type of wound healing.
  • It involved in energy production.
  • The body needs this amino acid to maintain muscle tissue as well. Decreases in this amino acid levels have been noted in extended endurance marathon runners and others following prolonged exercise.


Vitamin C deficiency will cause this amino acid to be lost in the urine because of collagen breakdown. This is an early symptom and precursor of degenerative disease.

The recommended therapeutic dose is between 500 milligrams and 1,000 milligrams/day, in combination with vitamin C.

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Proline side effects

People with liver or kidney disease should not take this amino acid supplement without first consulting their medical specialist. Getting too much of any amino acid can throw the citric acid (has an important role in our metabolism) cycle out of balance, which makes the kidneys and liver work harder to eliminate toxins. It is not recommended for people who have allergies to use supplements with this non-essential amino acid.


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