Zometa vs Reclast – Comparison of Uses & Side Effects 

Zometa

It is the brand name of a medication called zoledronic acid, that is part of a family of medications called bisphosphonates.

Contraindications

Before taking this bisphosphonate, tell your healthcare provider if you have:

  • if you are currently using any other bisphosphonate, like – alendronate, ibandronate, or tiludronate
  • allergy to zoledronic acid.

Mechanism of Action

It works by slowing the breakdown of bone.

Pregnancy & Breastfeeding

You should not breast-feed while using this bisphosphonate due to the fact that it passes into the breastmilk and negatively affects the breastfed baby.

This bisphosphonate can harm a developing fetus. Do not take this medication if you are pregnant.

Uses

This prescription medication is commonly used to prevent or delay bone problems due to cancer and to treat high blood calcium caused by cancer.

Drug Interactions

It may negatively interact with other medications, especially:

  • aspirin;
  • Reclast;
  • suboxone.

Dosage

The usual recommended dose is 4 mg IV over no less than 15 minutes, every 3 to 4 weeks. It is injected into a vein through an IV.

Important note – drink at least 2 glasses of water within a few hours before your injection to keep from getting dehydrated.

AlcoholAlcohol

Avoid drinking alcoholic beverages while taking this bisphosphonate since alcohol use can substantially increase the risk of side effects.

Side Effects and Precautions

Common side effects may include:

  • headache;
  • pain in your arms or legs;
  • trouble breathing;
  • constipation;
  • bone pain;
  • red or puffy eyes;
  • muscle or joint pain;
  • diarrhea;
  • nausea;
  • vomiting;
  • tiredness.

Less common side effects may include:

  • feeling tired or short of breath;
  • severe muscle pain;
  • little or no urination;
  • unusual pain in your thigh or hip;
  • swelling in your feet or ankles;
  • severe bone pain;
  • muscle spasms;
  • numbness feeling around your mouth or in your fingers;
  • jaw pain.

Reclast

It is the brand name of a drug called zoledronic acid, which is part of a family of drugs called bisphosphonates.

This medication is produced by Novartis, a pharmaceutical company with the headquarters in Basel.

Mechanism of Action

This drug works by slowing the breakdown of bone.

The US FDA first approved the medication in 2001.

Precautions

To make sure that this bisphosphonate is safe for you, tell your healthcare provider if you have ever had:

  • asthma caused by taking aspirin;
  • parathyroid surgery;
  • a dental problem;
  • thyroid surgery;
  • any condition which makes it hard for your body to absorb nutrients from food;
  • kidney disease;
  • hypocalcemia (low calcium levels in the blood serum);
  • surgery to remove part of your intestine.

Reclast For Osteoporosis

This prescription medication is used to treat and prevent glucocorticoid-induced osteoporosis and osteoporosis in postmenopausal women.

Moreover, this medication is used to treat Paget’s disease.

Pregnancy & Breastfeeding

This bisphosphonate may be harmful to an unborn baby. Tell your healthcare professional if you are pregnant or plan to fall pregnant during treatment.

This biphosphonate passes into breast milk and may negatively affect a nursing infant. Do not breastfeed while taking this medication without first talking to your doctor.

Dosage

For osteoporosis, the usual recommended dosage is 5 mg IV over >15 minutes every year.

Alcohol

Avoid drinking alcoholic beverages while taking this bisphosphonate because it can increase the risk of severe side effects, plus, alcohol may negatively affect your bone mineral density.

Side Effects and Precautions

Common side effects may include:

  • trouble breathing;
  • red or puffy eyes;
  • fever (high temperature) or other flu symptoms;
  • constipation;
  • bone pain;
  • tiredness;
  • muscle or joint pain;
  • diarrhea;
  • nausea;
  • pain in your legs or arms;
  • vomiting;
  • headaches.

Less common side effects may include:

  • swelling of your feet or ankles;
  • jaw numbness, pain, or swelling;
  • muscle contractions or spasms;
  • little or no urination;
  • feeling tired or short of breath;
  • severe bone, joint, or muscle pain;
  • numbness around your mouth;
  • numbness in your fingers and toes;
  • unusual pain in your hip or thigh.

Drug Interactions

It may negatively interact with other medications, especially:

  • aminoglycoside antibiotics, such as – Amikin (amikacin), Humatin (paromomycin), or streptomycin;
  • Lisinopril;
  • oral steroids, such as Dexone (dexamethasone), Medrol, or Deltasone (prednisone);
  • aspirin or other nonsteroidal anti-inflammatory drugs, like – Aleve or Motrin (ibuprofen);
  • diuretics, like – Edecrin (ethacrynic acid) or Lasix (furosemide);
  • Vivelle-Dot;
  • chemotherapy drugs for cancer;
  • Lanoxin or digoxin.

Bottom Line – Zometa vs Reclast

Zometa (active ingredient – zoledronic acid) is a medication that is to treat high blood levels of calcium caused by cancer. Also, this medication is used to treat multiple myeloma or bone cancer that has spread from elsewhere in the body.

Reclast (active ingredient – zoledronic acid) is a bisphosphonate that may help prevent bone fractures and can slow bone loss. In addition, it is used to treat or prevent osteoporosis caused by steroid use, menopause, or gonadal failure.

In conclusion, both medications have the same active ingredient, the only difference is concentration – Reclast 5 mg formulation, while Zometa has 4 mg.

Due to this difference in concentration, Reclast is prescribed for the treatment of osteoporosis in postmenopausal women, treatment of osteoporosis in men, prevention of osteoporosis in postmenopausal women, treatment and prevention of glucocorticoid-induced osteoporosis, and treatment of Paget’s disease of bone, and Zometa is prescribed for hypercalcemia of malignancy and multiple myeloma and bone metastases of solid tumors.

Regarding their price, the average retail price for 1 vial (5ml) of Zometa 4mg/5ml is $970, while the average retail price for 1 bottle (100ml) of Reclast 5mg/100ml solution is $1,110.

References    

https://www.nejm.org/doi/full/10.1056/NEJMoa067312
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4740633/
https://www.nejm.org/doi/full/10.1056/NEJMoa074941

 

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