Vemlidy vs Viread – detailed comparison:
Vemlidy
It is the brand name of a drug called tenofovir alafenamide, which belongs to a group of drugs known as nucleoside reverse transcriptase inhibitors.
Mechanism of Action
It works by stopping the virus from replicating.
Uses
This prescription medication is used to treat chronic hepatitis B virus (HBV) in combination with other antiviral medications in adults with stable (compensated) liver disease.
Dosage
The usual recommended dose is 25 mg (one tablet) taken orally once per day with food.
Side Effects and Precautions
Common side effects may include:
- feeling tired;
- diarrhea;
- back pain;
- dizziness;
- depressed mood;
- vomiting;
- headaches;
- a cough;
- nausea;
- sleep problems (insomnia);
- stomach pain;
- itching or rash;
- fever;
- changes in the shape or location of body fat;
- weakness.
Rare side effects may include::
- feeling short of breath;
- easy bruising or unusual bleeding;
- wheezing;
- flu symptoms;
- a dry cough;
- a sore throat;
- sores on your genital or anal area;
- problems with balance or eye movement;
- swelling of your feet or ankles;
- chest pain;
- weakness or prickly feeling;
- painful or difficult urination;
- feeling anxious or irritable;
- little or no urination;
- rapid heart rate;
- loss of interest in sex;
- jaundice (yellowing of the skin or eyes);
- weight loss;
- impotence;
- menstrual changes;
- loss of bladder or bowel control;
- swelling in your neck or throat;
- severe lower back pain;
- clay-colored stools;
- unusual tiredness.
Contraindications
To make sure that this medication is safe for you, tell your healthcare provider if you have:
- low bone mineral density;
- kidney disease;
- liver disease.
Alcohol
Avoid drinking alcoholic beverages while taking this medication since alcohol use can substantially increase the risk of severe side effects.
Drug Interactions
It may negatively interact with other medications, especially:
- emtricitabine;
- abacavir;
- Kaletra (lopinavir/ritonavir);
- Acetylsalicylic Acid (aspirin);
- lamivudine;
- adefovir;
- Paracetamol (acetaminophen);
- Aspir 81 (aspirin);
- Reyataz (atazanavir);
- atazanavir;
- Valproate Sodium (valproic acid);
- Chlorpheniramine;
- Wellbutrin XL (bupropion);
- didanosine;
- zidovudine;
- L-Arginine (arginine);
- Tramadol Hydrochloride ER (tramadol);
- Phenytoin Sodium (phenytoin).
Pregnancy & Breastfeeding
If you are pregnant, your name may be listed on a pregnancy registry to evaluate any effects of tenofovir on the developing fetus.
Do not breastfeed while taking this medication since it can pass into breast milk and may harm a nursing infant.
Viread
It is the brand name of a medication called tenofovir disoproxil fumarate, which belongs to the family of medications known as nucleoside reverse transcriptase inhibitors.
Mechanism of Action
This medication works by stopping the virus from replicating.
Uses
This prescription medication is used along with other medications to treat human immunodeficiency virus and chronic hepatitis B infections.
Dosage
The usual recommended dose is one tablet taken orally once per day with food.
Side Effects and Precautions
Common side effects may include:
- back pain;
- diarrhea;
- headaches;
- changes in the shape or location of body fat;
- vomiting;
- feeling tired;
- dizziness;
- nausea;
- weakness;
- depressed mood;
- stomach pain;
- sleep problems (insomnia);
- a cough;
- itching or rash;
- fever.
Rare side effects may include:
- feeling short of breath;
- easy bruising or unusual bleeding;
- unusual tiredness;
- wheezing;
- flu symptoms;
- clay-colored stools;
- a dry cough;
- a sore throat;
- severe lower back pain;
- sores on your genital or anal area;
- swelling in your neck or throat;
- problems with balance or eye movement;
- swelling of your feet or ankles;
- loss of bladder or bowel control;
- chest pain;
- weakness or prickly feeling;
- painful or difficult urination;
- feeling anxious or irritable;
- menstrual changes;
- little or no urination;
- rapid heart rate;
- loss of interest in sex;
- jaundice (yellowing of the skin or eyes);
- impotence;
- weight loss.
Contraindications
To make sure that this nucleoside reverse transcriptase inhibitor is safe for you, tell your healthcare provider if you have:
- low bone mineral density;
- kidney disease;
- liver disease.
Alcohol
Avoid drinking alcoholic beverages while taking this medication since alcohol use can substantially increase the risk of severe side effects.
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Drug Interactions
It may negatively interact with other medications, especially:
- Cymbalta (duloxetine);
- acyclovir;
- Isentress (raltegravir);
- aspirin;
- lisinopril;
- Baraclude (entecavir);
- Norvir (ritonavir);
- clonazepam;
- Prezista (darunavir);
- Emtriva (emtricitabine);
- tramadol;
- Epivir (lamivudine);
- Truvada (emtricitabine/tenofovir);
- gabapentin;
- Ziagen (abacavir);
- ibuprofen;
- sovaldi;
- trazodone;
- Kaletra (lopinavir/ritonavir);
- Reyataz (atazanavir);
- levothyroxine;
- omeprazole;
- zepatier;
- metformin.
Pregnancy & Breastfeeding
Do not breastfeed while taking this medication since it can pass into breast milk and may harm a nursing infant.
If you are pregnant, your name may be listed on a pregnancy registry to evaluate any effects of tenofovir on the developing fetus.
READ MORE: Odefsey vs Genvoya
Bottom Line – Vemlidy vs Viread
Vemlidy (active ingredient – tenofovir alafenamide) is an antiviral medicine that is used to treat chronic hepatitis B and HIV (the virus which can cause acquired immunodeficiency syndrome). It works by preventing hepatitis B virus or human immunodeficiency virus from multiplying in the body.
Viread (active ingredient – tenofovir disoproxil fumarate) is an antiviral medicine that is used to treat chronic hepatitis B and HIV (the virus which can cause acquired immunodeficiency syndrome). It works by preventing hepatitis B virus or human immunodeficiency virus from multiplying in the body.
In conclusion, both medications are generally well tolerated, and the rates of adverse events are around 1 percent. However, according to studies, Vemlidy has greater plasma stability compared to Viread, therefore, it can be given at a lower dose, resulting in less tenofovir in the bloodstream.
Also, Vemlidy has been shown to have similar antiviral effectiveness as Viread, but improved bone and kidney safety.
Regarding their price, the average retail price for 30 tablets of Vemlidy 25mg is $1,090, while the average retail price for 30 tablets of Viread 300mg is $310.
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References http://www.ema.europa.eu/docs/en_GB/document_library/EPAR_-_P http://www.who.int/selection_medicines/committees/expert/21/