Quercetin Side Effects Stomach, Thyroid and Drug Interactions

Quercetin is the most abundant flavonoid present in various types of vegetables, fruits, teas, wine and many other food items. Onions have the highest known quercetin content (200-600 mg/kg), with fruits in a close second with between 2 and 250 mg/kg. It is actually considered to be a plant pigment and that explains why it is found in abundance in deep colorful fruits and veggies.

It’s essential to note that a few studies have shown that quercetin has no side effects even in high doses and that the substance has many health benefits. It can also be used to heal a variety of ailments, such as:

Cancer

Among different diseases, cancer is still considered as the most detrimental for the survival of humans. This flavonoid has been said to have health benefits on people suffering from cancer, plus it may also lower the risk of certain cancers. In addition, this substance also deactivates enzymes that help cancer cells to grow, such as ovarian, bladder, breast, and colorectal cancer.

Bone health

It interacts with bones at a fundamental level, positively influencing the behavior of both bone-building cells: osteoblasts and osteoclasts. Also, it is a natural compound that assists optimal bone health.

Antioxidant properties

Because of its outstanding antioxidant effects, this compound is extremely effective in managing numerous inflammatory conditions that have a negative impact on human health, such as chronic fatigue, heart disease, and arthritis.

Physical exercise

It is possible that this substance can improve energy levels; as a matter of fact, it is used as an ingredient in certain athletic supplements. This is because of its capacity to improve blood circulation. A meta-analysis published in 2012 found that individuals who took this flavonoid increased their performance levels and their levels of endurance.

Heart health

There are recent studies conducted on some human populations which established that various types of flavonoids are capable of helping reduce the risk of atherosclerosis. Moreover, its capacity to prevent oxidative stress and its anti-inflammatory properties again come to the fore when it comes to your most vital organ.

Side Effects of Quercetin

Minor side effects may result from quercetin supplement use, such as blurred vision, swollen feet, and ankles, dizziness, fluid accumulation in the knee, dull ache or feeling of pressure or heaviness in legs, headache, itching skin near damaged veins, pounding in the ears, nervousness, or slow or fast heartbeat.

Furthermore, taking very high doses of this flavonoid (more than 1 gram per day) may interfere with your kidney health. In addition, some preliminary evidence exists that it may generate a byproduct, which leads to loss of protein function in your body. Other side effects include:

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Drug Interactions

It may interfere with the absorption and effect of a few types of drugs, including antibiotics because as an antioxidant, it competes for the same cellular receptors as many types of antibiotic medications.

Also, it may interfere with the body’s absorption of cyclosporine, an immunosuppressant drug broadly used in organ transplantation to prevent rejection. Moreover, the supplement must not be taken with calcium channel blockers for hypertension or with some of the hormone replacement drugs.

Thyroid Function 

Your thyroid gland is a small gland, normally weighing less than one ounce. The organ is located in the front part of the neck below the voice box and has the shape of a butterfly.

The thyroid keeps your metabolism under control through the action of thyroid hormone, that makes it by extracting iodine from the blood and incorporating it into thyroid hormones.

This strong flavonoid inhibits thyroid-restricted genes expression and thyroid function and decreases the expression of the thyroid peroxidase, thyrotropin receptor, and thyroglobulin genes.

Allergy

An allergic reaction to the supplement may occur in some individuals as a result of your immune system over-responding and mistake the flavonoid for a potentially toxic or harmful substance. When you experience an allergic reaction, one major mediator is histamine, a natural compound that the body releases when it perceives an invader has entered and is attacking. Histamine can cause itching, swelling, flushing, redness, and much discomfort.

Stomach 

Individuals with sensitive stomachs may also experience acid reflux or heartburn if larger doses are consumed on an empty stomach.

During pregnancy

There is no study regarding its safety for pregnant women but nor is there any negative evidence. If you feel concerned, take the safe option and consult your healthcare specialist.

Note

It is known that small amounts of the bioflavonoid, like the amounts that naturally occur in fruits, legumes, and vegetables, are 100% safe and beneficial. For example, the average American adult consuming a balanced diet consumes approximately 30 to 50 milligrams per day.

References

http://www.ncbi.nlm.nih.gov/pubmed/25482952
http://www.ncbi.nlm.nih.gov/pubmed/21606866

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