Metadate CD vs Concerta – Comparison Between Side Effects & Uses

Metadate CD

It is the brand name of a medication called methylphenidate hydrochloride, that belongs to a group of drugs known as central nervous system (CNS) stimulants.

This medication works by changing the amount of natural substances in the brain to decrease hyperactivity and impulsiveness.

Uses

This prescription medication is used to treat narcolepsy (a chronic sleep disorder that causes overwhelming daytime drowsiness) and attention deficit hyperactivity disorder.

Dosage

It comes in extended-release capsule and is taken once a day in the morning before breakfast.

Side Effects and Precautions

Common side effects may include:

  • headaches;
  • sleep problems (insomnia);
  • stomach pain;
  • feeling nervous or irritable;
  • nausea;
  • mood changes;
  • unexplained weight loss;
  • loss of appetite;
  • increased blood pressure;
  • fast heart rate.

Rare side effects may include:

  • skin color changes in your fingers or toes;
  • a feeling like you might pass out;
  • unexplained wounds;
  • trouble breathing;
  • paranoia;
  • chest pain;
  • a seizure (convulsions);
  • cold feeling;
  • muscle twitches;
  • hostility;
  • changes in your vision;
  • new behavior problems;
  • penis erection that lasts 4 hours or longer;
  • seeing or hearing things that are not real.

Contraindications

You should not use this medication if you have:

  • a congenital heart defect;
  • glaucoma;
  • high blood pressure;
  • Tourette’s syndrome;
  • heart disease;
  • a personal history of muscle twitches;
  • heart problems;
  • severe tension, anxiety, or agitation.

Alcoholalcohol

Avoid consuming alcoholic beverages while taking this medication since alcohol use may cause methylphenidate to be released into the bloodstream too fast.

Drug Interactionsg

It may negatively interact with other medications, especially:

  • Cymbalta (duloxetine);
  • Abilify (aripiprazole);
  • fluoxetine;
  • Adderall (amphetamine/dextroamphetamine);
  • ibuprofen;
  • Adderall XR (amphetamine / dextroamphetamine);
  • levothyroxine;
  • latisse;
  • clonazepam;
  • melatonin;
  • clonidine;
  • Ritalin (methylphenidate);
  • Concerta (methylphenidate);
  • Strattera (atomoxetine);
  • Depakote (divalproex sodium);
  • Vyvanse (lisdexamfetamine);
  • Focalin XR (dexmethylphenidate);
  • Zoloft (sertraline);
  • Aptensio XR;
  • gabapentin;
  • trazodone;
  • Klonopin (clonazepam);
  • Risperdal (risperidone);
  • Lamictal (lamotrigine).

Pregnancy & Breastfeeding

It is not exactly known whether this medication will harm a developing fetus. Tell your healthcare provider if you are pregnant or plan to fall pregnant before taking this medication.

It is not known exactly whether this medication passes into breast milk or if it could negatively affect a nursing infant. Tell your healthcare provider if you are breastfeeding an infant before taking this medication.

Concerta

It is the brand name of a drug called methylphenidate, which belongs to a group of drugs known as central nervous system stimulants.

This central nervous system stimulant works by changing the amount of natural substances in the brain to decrease hyperactivity and impulsiveness.

Uses

This medication is used to treat narcolepsy, attention deficit disorder, and attention deficit hyperactivity disorder.

Dosage

For children, the usual recommended dosage is 18 mg to 54 mg per day. For adolescents, the usual recommended dosage is 18 mg to 72 mg per day. For adults, the usual recommended dosage is 18 mg to 72 mg per day.

Important note – this central nervous system stimulant should be taken 30 to 45 minutes before a meal.

Pregnancy & Breastfeeding

It is not exactly known whether this medication will harm a developing fetus. Tell your healthcare provider if you are pregnant or plan to fall pregnant before taking this medication.

It is not known exactly whether this medication passes into breast milk or if it could negatively affect a nursing infant. Tell your healthcare provider if you are breastfeeding an infant before taking this medication.

Side Effects and Precautions

Common side effects may include:

  • mood changes;
  • weight loss;
  • fast heart rate;
  • sleep problems (insomnia);
  • increased blood pressure;
  • stomach pain;
  • loss of appetite;
  • feeling nervous or irritable;
  • nausea;
  • headaches.

Less common side effects may include:

  • muscle twitches;
  • paranoia;
  • numbness;
  • chest pain;
  • changes in your vision;
  • hostility;
  • hallucinations;
  • a feeling like you might pass out;
  • penis erection that is painful;
  • skin color changes in the fingers or toes;
  • cold feeling;
  • unexplained wounds;
  • new behavior problems;
  • trouble breathing;
  • aggression;
  • a seizure (convulsions).

Alcohol

Avoid drinking alcoholic beverages while taking this medication since alcohol use may cause methylphenidate to be released into the bloodstream too fast.

Contraindications

You should not use this medication if you have:

  • glaucoma;
  • severe anxiety;
  • a personal history of muscle twitches;
  • Tourette’s syndrome.

Drug Interactions

It may negatively interact with other medications, especially:

  • temazepam;
  • aripiprazole;
  • lamotrigine;
  • clonazepam;
  • doxycycline;
  • BuSpar (buspirone);
  • alprazolam;
  • Abilify (aripiprazole);
  • venlafaxine;
  • cyclobenzaprine;
  • unisom;
  • hydroxyzine;
  • melatonin;
  • adapalene topical;
  • Trintellix (vortioxetine);
  • gabapentin;
  • trazodone;
  • losartan;
  • sertraline;
  • Adderall XR (amphetamine/dextroamphetamine).

Bottom Line – Metadate CD vs Concerta

Metadate CD (active ingredient – methylphenidate) is a central nervous system stimulant that is used to treat attention deficit hyperactivity disorder, attention deficit disorder, and narcolepsy. It works by affecting the chemicals in the brain and nerves which contribute to hyperactivity and impulse control.

It releases methylphenidate from beads (30 percent immediate release and 70 percent extended release) to mimic the effect of 2 doses of immediate-release methylphenidate. Peak plasma concentrations develop at 1.5 and 4.5 hours after intake.

Concerta (active ingredient – methylphenidate) is a central nervous system stimulant medication which is used to treat narcolepsy, attention deficit hyperactivity disorder, and attention deficit disorder. It works by affecting the chemicals in the brain and nerves which contribute to hyperactivity and impulse control. This medication has a duration of action of 10-12 hours.

References

https://www.ncbi.nlm.nih.gov/pubmed/12487502
https://www.cdc.gov/ncbddd/adhd/research.html

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