Lisinopril vs Amlodipine – Comparison of Uses & Side Effects


It is a medication that belongs to a group of drugs called angiotensin-converting enzyme inhibitors (brand Names: Prinivil, Qbrelis, Zestril), that relax blood vessels to lower blood pressure and make the heart pump better.

The US Food and Drug Administration originally approved it in 1987.


This type of angiotensin-converting enzyme inhibitor is used to treat diabetic hypertension, nephropathy, and congestive heart failure.

Hypertension is a common condition that can cause severe damage to the heart, brain, kidneys, blood vessels, and other parts of the body when left untreated. Damage to these vital organs may cause heart disease, a heart failure, heart attack, stroke, loss of vision, kidney failure, and other health problems.

In addition, it is used immediately after a heart attack in order to reduce the risk of having another heart attack.


Most healthcare professionals will recommend that the patient starts with a low dose, like – 5mg, as the body gets used to taking the medication. Several weeks later, the dose can be increased until the patient eventually reaches the optimal dose.

Note – the peak effect of this drug can be observed in 6 to 8 hours. The effect of this angiotensin-converting enzyme inhibitor lasts for an average duration of 24 hours.

More importantly, it is not recommended in children less than 6 years of age.

Side Effects and Precautions

Common side effects may include:

  • a cough;
  • dizziness;
  • chest pain;
  • headaches.

Rare side effects may include:

  • a sore throat;
  • a feeling like you might pass out;
  • weakness;
  • fever;
  • loss of movement;
  • upper stomach pain;
  • irregular heartbeats;
  • nausea;
  • tired feeling;
  • loss of appetite;
  • chest pain;
  • swelling of your feet or ankles;
  • jaundice (yellowing of the skin or eyes);
  • clay-colored stools;
  • dark urine;
  • feeling short of breath.

Pregnancy & Breastfeeding

Fetal mortality may occur when this angiotensin-converting enzyme inhibitor is used in pregnancy. Avoid this drug as soon as possible once the pregnancy is detected. It should also be avoided by nursing women.

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Drinking alcoholic beverages can increase the blood pressure lowering effect of the medication and can make you feel dizzier and more likely to faint.

Drug Interactions

This medication may negatively interact with other drugs, especially:

  • amiloride (Midamor);
  • hydrochlorothiazide;
  • spironolactone (Aldactone);
  • aliskiren (Tekturna);
  • triamterene (Dyrenium);
  • celecoxib (Celebrex);
  • furosemide (Lasix);
  • ibuprofen (Advil, Motrin, Nuprin);
  • torsemide (Demadex);
  • ketorolac (Toradol);
  • angiotensin receptor blockers, like candesartan (Atacand) and telmisartan (Micardis, Twynsta);
  • nabumetone (Relafen);
  • diclofenac (Cambia, Voltaren, Zipsor);
  • naproxen sodium (Aleve, Naprelan);
  • etodolac (Lodine);
  • oxaprozin (Daypro);
  • indomethacin (Indocin, Indocin SR);
  • injectable gold (sodium aurothiomalate);
  • ketoprofen (Orudis, Oruvail);
  • potassium supplements;
  • meloxicam (Mobic);
  • lithium (Eskalith, Lithobid);
  • piroxicam (Feldene);
  • naproxen (Naprosyn).


It is a medication that belongs to a class of drugs called calcium channel blockers (brand name – Norvasc). It works by relaxing the blood vessels and improving blood flow. This helps lower blood pressure.


This channel blocker is used to help blood flow more easily to the heart when the arteries in the heart are blocked.

It is also used to lower blood pressure. It can be used alone or in combination with other heart drugs.


The usual recommended starting dose is 5mg once per day. If the starting dose is not working well enough, the dose may need to be increased to 10mg a day.

Note – you can take this channel blocker at any time of day, but try to make sure it is around the same time every day. It can be taken by adults and children aged 6 years and over.

Side Effects and Precautions

Common side effects may include:

  • feeling tired;
  • dizziness;
  • nausea;
  • stomach pain;
  • redness, warmth, or tingly feeling.

Rare side effects may include:

  • worsening chest pain;
  • fluttering in your chest;
  • swelling in your feet or ankles;
  • pounding heartbeats;
  • a light-headed feeling, like you might pass out;
  • severe drowsiness.
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Pregnancy & Breastfeeding

It is not known precisely if the medication is excreted in human breast milk or if it will harm a nursing baby, hence, tell your doctor if you are breast-feeding a baby.

This channel blocker should be used during pregnancy only if the potential benefit justifies the potential risk to the developing baby.


Drinking alcoholic beverages can further lower your blood pressure and may increase other side effects of the medication.

Drug Interactions

It may negatively interact with other drugs, especially:

  • simvastatin;
  • diltiazem (Cardizem, Tiazac);
  • ritonavir (Norvir);
  • itraconazole (Sporanox);
  • ketoconazole (Nizoral).

Bottom Line – Lisinopril vs Amlodipine

Lisinopril (brand Names: Prinivil, Qbrelis, Zestril) is an angiotensin-converting enzyme that is used to improve survival after a heart attack or to treat congestive heart failure in adults. It is used to treat high blood pressure in adults and children who are at least 6 years old.

Amlodipine (brand name – Norvasc) is a calcium channel blocker which widens blood vessels and improves blood flow. It is used to treat high blood pressure as well as chest pain caused by coronary artery disease.

According to a 1998 study done at the Department of Medical Cardiology, UK, amlodipine showed more consistent control of blood pressure over the 24-h period in contrast to lisinopril that exerted its greatest effect during the daytime. Tolerability was good during both treatments and there were no serious adverse events.



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