Genvoya vs Stribild For HIV – Differences & Side Effects

Genvoya

It is the brand name of a combination of emtricitabine, tenofovir, cobicistat, and elvitegravir.

Emtricitabine, tenofovir, and elvitegravir are antiviral drugs that prevent human immunodeficiency virus from multiplying in the human body.

Cobicistat is a drug which works by reducing the action of enzymes in the liver that break down certain antiviral medications.

Together, these medications are antiretroviral drugs.

Uses

This prescription medication is used to treat human immunodeficiency virus. HIV is a virus that attacks the immune system.

AIDS (acquired immunodeficiency syndrome) is a condition caused by human immunodeficiency virus. Symptoms of early HIV infection may include:

  • tiredness;
  • joint pain;
  • enlarged glands;
  • fever;
  • muscle aches;
  • a sore throat;
  • sweats;
  • chills;
  • a red rash;
  • weakness;
  • unintentional weight loss.

Important note – this medication can’t cure HIV/AIDS, but it can help people with HIV taking it regularly to live longer.

Dosage

For patients 12 years and older who weigh ≥35kg, the usual recommended dose is 1 tablet taken orally once a day.

Precautions

Before taking this medication, tell your healthcare provider:

  • if you are using hormone-based birth control, like – implants, pills, or vaginal rings;
  • if you are breastfeeding or plan to breastfeed;
  • about other OTC and prescription medicines, nutritional supplements, vitamins, and herbal products you plan to take or are taking;
  • if you are allergic to any other medicines;
  • if you have liver problems, such as – hepatitis B virus infection;
  • if you are pregnant or plan to become pregnant;
  • if you have kidney problems;
  • if you have any other medical conditions.

Side Effects

Common side effects may include:

  • diarrhea;
  • headaches;
  • nausea;
  • fatigue.

Less common side effects may include:

  • indigestion;
  • rash;
  • flatulence;
  • abdominal pain;
  • yellowing of your skin or the whites of the eyes;
  • light-colored bowel movements;
  • dark-colored urine;
  • vomiting;
  • loss of appetite;
  • pain in the right side of the stomach.

Pregnancy & Breastfeeding

Women with HIV or AIDS should not breast-feed an infant. Even if your baby is born without human immunodeficiency virus, the virus may be passed to the baby through your breast milk.

If you are pregnant, your name may be listed on a pregnancy registry to evaluate any effects of this medication on the developing fetus.

Drug Interactionsdrugs pills

It may negatively interact with other medications, especially:

  • lurasidone;
  • pimozide;
  • dihydroergotamine;
  • methylergonovine;
  • phenytoin;
  • carbamazepine;
  • rifampin;
  • phenobarbital;
  • alfuzosin;
  • gleevec;
  • sildenafil;
  • simvastatin;
  • oral midazolam;
  • triazolam;
  • lovastatin.

Alcoholalcohol

Do not drink alcoholic beverages while taking this medication since alcohol use may increase the risk of severe side effects.

Stribild

Image credit – https://commons.wikimedia.org/wiki/File:Stribild_bottle_Dutch_labeling.jpg

It is the brand name of a combination of emtricitabine, tenofovir, cobicistat, and elvitegravir.

Elvitegravir belongs to a group of medications called HIV integrase strand transfer inhibitor. Cobicistat belongs to a group of drugs called CYP3A inhibitors and helps to keep elvitegravir in the body longer so that the medication will have a greater effect.

Tenofovir and emtricitabine belong to a group of drugs called nucleoside reverse transcriptase inhibitors.

Uses

This prescription medication is used to treat human immunodeficiency virus in adults who have never taken HIV drugs before.

Dosage

The usually recommended dose is 1 tablet orally once per day with food.

Side Effects and Precautions

Common side effects may include:

  • diarrhea;
  • nausea;
  • headaches;
  • fatigue.

Rare side effects may include:

  • little or no urination;
  • changes in the shape or location of body fat;
  • jaundice (yellowing of the skin or eyes);
  • feeling short of breath;
  • swelling of your feet or ankles;
  • clay-colored stools;
  • swollen glands;
  • dizziness;
  • weight loss;
  • stomach pain;
  • sores on your genital or anal area;
  • a dry cough;
  • loss of bladder or bowel control;
  • fast or irregular heartbeats;
  • loss of interest in sex;
  • numbness or cold feeling in your legs;
  • impotence;
  • muscle pain or weakness;
  • menstrual changes;
  • mouth sores;
  • swelling in your neck or throat;
  • severe lower back pain;
  • upper stomach pain;
  • problems with balance;
  • feeling anxious or irritable.

Contraindications

To make sure that this medication is safe for you, tell your healthcare provider if you have ever had:

  • kidney disease;
  • liver problems.

Alcohol

Do not drink alcoholic beverages while taking this medication since alcohol use may increase the risk of severe side effects.

Drug Interactions

It may negatively interact with other medications, especially:

  • Cymbalta (duloxetine);
  • Adderall (amphetamine/dextroamphetamine);
  • gabapentin;
  • Advil (ibuprofen);
  • lisinopril;
  • aspirin;
  • darunavir;
  • atazanavir;
  • geodon;
  • Prezista (darunavir);
  • atorvastatin;
  • testosterone;
  • Benadryl (diphenhydramine);
  • Tylenol (acetaminophen);
  • bupropion;
  • Truvada (emtricitabine/tenofovir);
  • Xanax (alprazolam);
  • clonazepam;
  • zolpidem;
  • grapefruit;
  • valacyclovir;
  • ibuprofen;
  • tramadol;
  • lorazepam;
  • sertraline;
  • oxycodone;
  • omeprazole.

Pregnancy & Breastfeeding

If you are pregnant, your name may be listed on a pregnancy registry to evaluate any effects of this medication on the developing fetus.

Women with HIV or AIDS should not breast-feed an infant. Even if your baby is born without human immunodeficiency virus, the virus may be passed to the baby through your breast milk.

Bottom Line – Genvoya vs Stribild

Genvoya (active ingredients – cobicistat, tenofovir, elvitegravir, and emtricitabine) is a combination medication which is used to treat human immunodeficiency virus infection.

It works by blocking a chemical in the body that is required for HIV-1 to multiply as well as it increases the number of T cells. This medication belongs to a group of drugs called HIV integrase strand transfer inhibitor.

Stribild (active ingredients – elvitegravir, emtricitabine, cobicistat, and tenofovir) is a medication that is used to treat human immunodeficiency virus in adults who have never taken HIV drugs before.

Both medications have almost identical combination drugs, differing only in the TAF (tenofovir alafenamide) vs TDF (tenofovir disoproxil fumarate) formulation of tenofovir. In studies, TAF has been shown to be less toxic to kidneys and bones than TDF.

In addition, both are produced by Gilead Sciences, Inc. Regarding their price, Stribild’s estimated annual cost is $28,500, while Genvoya’s estimated annual cost is $31,362.

References

https://aidsinfo.nih.gov/clinical-trials/search/quick/1/category/
http://www.gilead.com/news/press-releases/2013/10/gileads-single
https://journals.lww.com/jaids/Documents/QAIv64n4(suppl)-issue

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