Indomethacin vs Ibuprofen – Comparison of Side Effects & Uses

Indomethacin

It is the generic name of a drug that belongs to a group of drugs called non-steroidal anti-inflammatory drugs (NSAIDs). It can be found under the brand name of Indocin and Tivorbex.

Mechanism of Action

This medication works by stopping the body’s production of a substance that causes fever, pain, and inflammation.

The US Food and Drug Administration first approved this medication in 1965.

Uses

This prescription medication is used to relieve moderate to tenderness, severe pain, and swelling caused by several conditions.

Dosage

For pain, the usual recommended dose is 20 to 40 mg orally 3 times per day.

Note – children 14 years old and younger should not take this medication.

Side Effects and Precautions

Common side effects may include:

  • feeling tired;
  • vomiting;
  • drowsiness;
  • nausea;
  • ringing in your ears;
  • dizziness;
  • constipation;
  • headache;
  • diarrhea;
  • upset stomach.

Rare side effects may include:

  • coughing up vomit that looks like coffee grounds;
  • changes in your vision;
  • rapid weight gain;
  • shortness of breath;
  • skin pain followed by a red or purple skin rash;
  • bloody or tarry stools;
  • burning in your eyes;
  • upper stomach pain;
  • swelling in your facemâ, feet, ankles, or tongue;
  • jaundice (yellowing of the skin or eyes);
  • trouble concentrating;
  • nausea;
  • sore throat;
  • rapid heart rate;
  • clay-colored stools;
  • dark urine.

Contraindications

Before taking this non-steroidal anti-inflammatory drug, tell your healthcare provider if you have:

  • asthma;
  • diabetes;
  • kidney disease;
  • high LDL and total cholesterol levels;
  • liver disease;
  • a history of heart attack;
  • high blood pressure;
  • fluid retention;
  • a history of stomach ulcers;
  • heart disease.

Alcohol

Avoid drinking alcoholic beverages while taking this non-steroidal anti-inflammatory drug since alcohol use can substantially increase the risk of severe side effects.

Drug Interactions

It may negatively interact with other medications, especially:

  • Zoloft (sertraline);
  • Aspirin Low Strength (aspirin);
  • prednisone;
  • Tylenol;
  • Celebrex (celecoxib);
  • Cymbalta (duloxetine).

Pregnancy & Breastfeeding

Do not take this non-steroidal anti-inflammatory drug if you are because it can pass into breast milk and it negatively affects the breastfed infant.

Do not take this non-steroidal anti-inflammatory drug if you are pregnant since it may cause heart defects to the unborn baby, especially during later stages of pregnancy.

Ibuprofeng

It is the generic name of a drug that belongs to a group of drugs called non-steroidal anti-inflammatory drugs (NSAIDs). It can be found under the brand name of Motrin or Advil.

Uses

This medication is used to lower a high temperature, relieve the symptoms of fever and arthritis, and some types of pain, including:

  • sprains and strains;
  • migraines;
  • menstrual pain;
  • muscular pain;
  • backaches;
  • nerve pain (neuralgia);
  • headaches;
  • toothaches.

It is produced by McNeil Consumer Healthcare, an American medical products company that belongs to the Johnson & Johnson healthcare group.

The US Food and Drug Administration first approved it under the Motrin brand in 1974.

Mechanism of Action

This medication is a nonsteroidal anti-inflammatory drug which works by reducing the production of prostaglandins.

Dosage

To reduce pain, the usual recommended dosage for an adult is 200 to 400 mg orally every 4 to 6 hours as required. The maximum dosage is 3200 mg a day, divided into 3 or 4 doses.

Contraindications

Before taking this medication, tell your healthcare provider if you have:

  • asthma;
  • diabetes;
  • a history of stomach ulcers;
  • high cholesterol;
  • kidney disease;
  • heart disease;
  • a history of blood clot;
  • liver disease;
  • high blood pressure;
  • a connective tissue disease;
  • fluid retention.

Pregnancy & Breastfeeding

Since there are no well-controlled clinical studies in pregnant women, this nonsteroidal anti-inflammatory drug is best to be avoided especially in late pregnancy because of the risk of premature closure of the ductus arteriosus in the fetal heart.

It is not known exactly whether this medication passes into human breast milk or if it could negatively affect a breastfed infant. Tell your healthcare provider that you are breastfeeding a baby before using this medication.

Alcohol

It is not recommended to drink alcoholic beverages while taking a non-steroidal anti-inflammatory drug. Doing so could trigger potentially serious side effects.

Drug Interactions

It may negatively interact with other medications, especially:

  • beta blockers, such as – Zebeta (bisoprolol) or Coreg (carvedilol);
  • aspirin (both pill and suppository forms);
  • Eliquis (apixaban);
  • antidepressants, like – Paxil (paroxetine) and Lexapro (escitalopram);
  • water pills;
  • Tylenol;
  • other non-steroidal anti-inflammatory drugs, such as – Celebrex (celecoxib) or Relafen (nabumetone);
  • cancer drugs, like – Alimta (Pemetrexed);
  • blood thinners, such as – Pradaxa (dabigatran) or Coumadin (warfarin);
  • Stirbild (elvitegravir/cobicistat/emtricitabine/tenofovir).

Side Effects And Precautions

Common side effects may include:

  • ringing in the ears;
  • mild itching or rash;
  • mild heartburn;
  • constipation;
  • bloating;
  • dizziness;
  • nausea;
  • nervousness;
  • upset stomach;
  • diarrhea;
  • excessive gas;
  • vomiting.

Less common side effects may include:

  • feeling light-headed;
  • shortness of breath;
  • burning in the eyes;
  • a sore throat;
  • rapid heart rate;
  • yellowing of the skin or eyes;
  • clay-colored stools;
  • rapid weight gain;
  • trouble concentrating;
  • dark urine;
  • coughing up blood;
  • swelling of the ankles, face, tongue, or feet;
  • loss of appetite;
  • changes in your vision;
  • little or no urinating;
  • skin pain followed by a purple skin rash;
  • painful urination;
  • bloody or tarry stools.

Bottom Line – Indomethacin vs Ibuprofen      

Indomethacin (brand name – Indocin) is a prescription drug that belongs to a class of drugs called non-steroidal anti-inflammatory drugs (NSAIDs). It is used to treat moderate to severe pain, swelling, and stiffness from arthritis

Ibuprofen (brand names – Advil, Motrin, and Ibuprin) is a medication that belongs to a group of drugs known as non-steroidal anti-inflammatory drugs. It is used to lower a high temperature, relieve the symptoms of fever and arthritis, and some types of pain. This medication works by inhibiting prostaglandins, chemicals that can cause inflammation in the body.

According to a 2000 study, ibuprofen therapy on the third day of life is as efficacious as indomethacin for the treatment of patent ductus arteriosus in preterm infants with the respiratory distress syndrome.

Regarding their price, the average retail price for 90 capsules of indomethacin 50mg is $24, while the average retail price for 90 tablets of ibuprofen 800mg is $12.

References

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1427762/
https://www.ncbi.nlm.nih.gov/pubmed/6873148
https://www.ncbi.nlm.nih.gov/pubmed/10211650

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